PYRIDO[1,2-A]PYRIMIDONE ANALOG, ITS CRYSTAL FORM, ITS INTERMEDIATE COMPOUND AND METHOD FOR THEIR PREPARATION Russian patent published in 2021 - IPC C07D471/04 A61K31/519 A61P35/00 

Abstract RU 2753696 C2

FIELD: medicine.

SUBSTANCE: invention relates to forms of a compound 1 selected from a group consisting of a crystal form IX of the compound 1, hydrochloride salt of the compound 1 (compound 2), crystal forms I-VI of the compound 2, maleic salt of the compound 1 (compound 3), crystal form VII of the compound 3, lemon salt of the compound 1 (compound 4), crystal form VIII of the compound 4, where the specified crystal forms are characterized by X-ray diffraction patterns on the powder such as specified in the claims. The invention also relates to a pharmaceutical composition containing the specified forms, their application and a method for treating cancer.

EFFECT: proposed are forms of the compound 1 that inhibit PI3K kinase and that are suitable for the treatment of cancer related to PI3K kinase.

44 cl, 27 dwg, 13 tbl, 14 ex

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RU 2 753 696 C2

Authors

Yu, Tao

Li, Ning

Kong, Lingwei

Jiang, Peipei

Wang, Yong

Rong, Zhemin

Wang, Changjun

Guo, Feng

Li, Zongbin

Wang, Zheng

Wu, Jiahu

Wu, Chengde

Dates

2021-08-19Published

2016-12-16Filed