ATR INHIBITOR AND ITS USE Russian patent published in 2023 - IPC C07D413/14 C07D471/04 A61K31/437 A61P35/00 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a compound of formula (IА) or a pharmaceutically acceptable salt thereof. In formula (I): n is either 1, 2, 3 or 4; structural unit selected from the group consisting of , ring A is selected from the group consisting of 5–6 membered heteroaryl; each R₁ is independently selected from the group consisting of H, F, Cl, Br, I, C_1-6 alkyl, C_1-6 alkoxy and C_3-6 cycloalkyl, with C_1-6 alkyl, C_1-6 alkoxy and C_3-6 cycloalkyl are optionally substituted with 1, 2 or 3 R; each R₂ is independently selected from the group consisting of H, F, Cl, Br, I, COOH, and C_1-3 alkyl, with C_1-3 alkyl optionally substituted with 1, 2, or 3 R; each R is independently selected from the group consisting of F, Cl, Br, I, OH, C_1-3 alkyl and C_1-3 alkoxy, with C_1-3 alkyl and C_1-3 alkoxy optionally substituted with 1, 2 or 3 R'; every R' independently selected from the group consisting of F, Cl, Br, I and OH; A 5–6 membered heteroaryl contains 1, 2, 3 or 4 heteroatoms or heteroradicals independently selected from the group consisting of -NH-, -O- and N; and Z₁ is N, Z₂ and Z₃ are CH; Z₂ is N, Z₁ and Z₃ are CH; Z₃ is N, Z₁ and Z₂ are CH; Z₁ and Z₂ are N, Z₃ is CH; Z₂ and Z ₃ are N, Z₁ is CH; or Z₁ and Z₃ are N, Z₂ is CH. Also the use of the said compound for the manufacture of a medicinal product is proposed.

EFFECT: proposed compound can be used as an ATR inhibitor.

15 cl, 1 dwg, 4 tbl, 61 ex