MODIFIER OF DERIVATIVE OF FOUR-MEMBERED RING, METHOD FOR PRODUCTION THEREOF AND USE THEREOF Russian patent published in 2025 - IPC C07D241/04 A61K31/495 A61P25/00 

FIELD: chemistry.

SUBSTANCE: present invention relates to a compound of formula (IX-A), a stereoisomer thereof or a pharmaceutically acceptable salt thereof, a method of producing said compound and use thereof: . In formula IX-A, R₄ is selected from a group consisting of , , , and ; R_a is selected from a group consisting of hydrogen or C_1-6 alkyl; R_b selected from a group consisting of hydrogen, amino, C_1-6 alkyl, C_1-6 alkoxy, C_3-8 cycloalkyl, 3–8-membered heterocyclyl containing 1 or 2 heteroatoms, selected from O, N, S, and 5–10-membered heteroaryl containing 1 or 2 heteroatoms selected from O, N, S, wherein each said amino, C_1-6 alkyl, C_3-8 cycloalkyl, 3–8-membered heterocyclyl and 5–10-membered heteroaryl is optionally further substituted with one or more substitutes, selected from the group consisting of halogen, hydroxy, cyano, C_1-6 alkyl, C_1-6 alkoxy or C_3-8 cycloalkyl; R₅ is selected from hydrogen, C_1-6 alkyl or halogen; or any adjacent two R₅ are bonded to form 5–6-membered heteroaryl containing 1 heteroatom selected from N, S or O; r is 0 or 1; m is 0 or 1; t is equal to 2.

EFFECT: obtaining novel compounds which can be used as G-protein coupled receptor modulators, as well as in treating or preventing central nervous system diseases and/or mental diseases.

31 cl, 7 tbl, 31 ex