FGFR INHIBITOR, METHOD FOR PRODUCTION AND APPLICATION THEREOF Russian patent published in 2022 - IPC C07D239/42 C07D239/84 C07D217/06 C07D403/04 C07D471/04 A61K31/437 A61K31/505 A61K31/506 A61K31/519 A61P35/00 

FIELD: pharmaceuticals.

SUBSTANCE: proposed is a compound by the formula (II), a stereoisomer, prodrug or pharmacologically acceptable salt thereof, wherein X constitutes CH; R₁ is selected from the group consisting of a C_1-3 alkyl, a C₅ cycloalkyl and a 4-6-membered heterocyclyl, optionally substituted with one or multiple additional substituents, R₂ constitutes phenyl, pyridyl or pyrazolyl, optionally substituted with one or multiple additional substituents; R₃ constitutes a methoxy; R₄ is independently selected from the group consisting of H, F and Cl; R₁₀ constitutes a C₁ alkyl; R₁₃ and R₁₄ each independently constitute a C₁ alkyl; r is 2; wherein, unless otherwise indicated, the heteroatom of heterocyclyl in the above substituents is selected from 1-2 nitrogen or oxygen atoms. Also proposed are a method for production and an application of a compound acting as an FGFR inhibitor for treating tumours, malignant neoplasms, myeloproliferative diseases, diseases of cells of bone and cartilaginous tissue, and hypophosphatemia.

EFFECT: production of heteroaromatic compounds applicable as an FGFR inhibitor.

9 cl, 10 ex, 2 tbl