FIELD: pharmacology.
SUBSTANCE: invention relates to new compounds of formula 
I, their optical isomers or pharmaceutically acceptable salts that can be used for treatment of diseases mediated by histone deacetylase. In formula I, A is 
, Xa and Xb are CH, L1 and L2 independently hydrogen, -F, -Cl, -Br or -I, Q is C(=O), Y is selected from the group consisting of 
, and , M is C, O or N, l and m are independently 0 or 1, each of Ra1 and Ra2 is independently hydrogen; hydroxy; linear or branched -C1-4-alkyl, etc., n is 0, 1 or 2, Rb is hydrogen; hydroxy; linear or branched -C1-6-alkyl, etc., Z is selected from the group consisting of 
, etc., where each of Pa and Pb is independently 
; hydrogen; hydroxy; linear or branched -C1-4-alkyl, etc., where 
is selected from phenyl, pyridine, pyrimidine, thiazole, indole, indazole, etc., each of x, y and z is independently 0 or 1, and each of Rg1, Rg2 and Rg3 is selected independently from hydrogen; hydroxy; -C1-3-alkyl, etc. The invention also relates to a pharmaceutical composition comprising compounds of formula I, a method for treatment of diseases mediated by histone deacetylase and application of said compounds for drugs preparation.
EFFECT: increased effeciency of compound application.
9 cl, 7 dwg, 16 tbl, 173 ex
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