NEUROACTIVE STEROIDS, COMPOSITIONS AND USES THEREOF Russian patent published in 2018 - IPC C07J41/00 C07J31/00 C07J9/00 A61K31/57 A61K31/575 A61P25/18 A61P25/28 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (I-a1) or a pharmaceutically acceptable salt thereof. In formula (I-a1), Z represents a group of formulae (iv) (iv); L³ is C₁-C₆alkylene; R^3b is hydrogen; R^3a is C₁-C₆alkyl; -OR^3b is in the beta position and R^3a is in the alpha position; each of R², R^11a and R^11b is hydrogen; R^6a is hydrogen; Y is -O-; R^Z5 is hydrogen; each of R^Z6 is independently hydrogen or C₁-C₆alkyl. Invention also relates to a pharmaceutical composition and to a method for preventing, treating, improving a condition or controlling a disease or pathological condition mediated by the NMDA receptor modulator. (I-a1).

EFFECT: technical result: novel compounds of formula (I-a1), which are potential modulators of NMDA receptors, are obtained.

7 cl, 37 ex