NEUROACTIVE STEROIDS, COMPOSITIONS AND THEIR USE Russian patent published in 2023 - IPC C07J41/00 C07J31/00 C07J9/00 A61K31/57 A61K31/575 A61P25/18 A61P25/28 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a compound of formula (I-a2) or (I-a3) or a pharmaceutically acceptable salt thereof, where Z represents a group of formula (iv), L³ represents an unsubstituted C₁-C₆ alkylene, C₁-C₆ alkylene, substituted by methyl, unsubstituted hetero-C₁-C₆ alkylene containing an O atom as a heteroatom, or hetero-C₁-C₆ alkylene containing an O atom as a heteroatom, substituted by methyl; R^3b represents hydrogen; R^3a represents unsubstituted C₁-C₆ alkyl or C₁-C₆ alkyl substituted with 1–3 fluorine atoms or a methoxy group; R² represents hydrogen; each of R^11a and R^11b independently represents hydrogen; R^6a and R^6b are each hydrogen, unsubstituted C₁-C₆ alkyl or halogen; Y represents -O-; R^Z5 represents hydrogen; and R ^Z6 is in each case independently hydrogen or unsubstituted C₁-C₆ alkyl. The invention relates to a pharmaceutical composition with activity against the NMDA receptor, containing a pharmaceutically acceptable carrier and an effective amount of a compound of the invention or a pharmaceutically acceptable salt thereof. The invention also provides a method of treating, ameliorating or controlling a disease or condition mediated by an NMDA receptor, which comprises administering to a patient in need of such treatment, amelioration or control a therapeutically effective amount of a compound of the invention or a pharmaceutically acceptable salt or a pharmaceutical composition thereof.

EFFECT: obtaining 3α- and 3β-hydroxysteroids with NMDA receptor activity.

19 cl, 1 tbl, 37 ex