METHOD FOR INCREASING PHYSICAL ENDURANCE IN EXPERIMENT ON DYSFERLIN-DEFICIENT MICE Russian patent published in 2025 - IPC A61K48/00 C12N15/113 C12N15/63 C12N15/864 

FIELD: medicine; pharmacology.

SUBSTANCE: invention relates to experimental pharmacology and genetic technologies. Disclosed is a method for increasing physical endurance in experiment on dysferlin-deficient mice. Male dysferlin-deficient mice B6.A/J-Dysf^prmd single introduction of a two-vector preparation based on adeno-associated virus of serotype 9 containing a vector pAAV-Dysf5'-DV, bearing 5'-sequence of dysferlin cDNA, muscle-specific promoter MHCK7, chimeric intron, left inverted terminal repeat (L-ITR) and right inverted terminal repeat (R-ITR); and vector pAAV-Dysf3'-DV, bearing 3'-sequence of dysferlin cDNA, L-ITR, PolyA SV40 and R-ITR.

EFFECT: method leads to increased physical endurance in experiment on dysferlin-deficient mice, which is confirmed by results of test "retention on wire" in 3 months after introduction of the preparation.

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