METHOD FOR IMPROVING PHYSICAL PERFORMANCE USING ADENO-ASSOCIATED VIRAL VECTOR IN EXPERIMENT ON DYSFERLIN-DEFICIENT MICE Russian patent published in 2024 - IPC C12N1/00 

Abstract RU 2828839 C1

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly to experimental pharmacology and genetic technologies. Described method is as follows. In dysferlin-deficient mice B6.A/J-Dysfprmd there is a marked increase in the duration of swimming with a load after a single introduction of a preparation based on adeno-associated virus of serotype 9 in dose of 1*1012 units of virus with the DYSF gene in amount of 50 mcl in the following muscles of both hind limbs: m. vastus lateralis, m. tibialis anterior, m. gastrocnemius lateralis (per animal in total 300 mcl) in test "Forced swimming with load" in 3 months after introduction of AAV9-DYSF-DV.

EFFECT: invention can be used to improve physical performance.

1 cl, 1 dwg, 3 tbl, 1 ex

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RU 2 828 839 C1

Authors

Korokin Mikhail Viktorovich

Pokrovskii Mikhail Vladimirovich

Deikin Aleksei Vasilevich

Korokina Liliia Viktorovna

Peresypkina Anna Aleksandrovna

Gudyrev Oleg Sergeevich

Deev Roman Vadimovich

Kuzubova Elena Valerevna

Iakovlev Ivan Antonovich

Isaev Artur Aleksandrovich

Pokrovskii Vladimir Mikhailovich

Zhunusov Nikita Sergeevich

Kraiushkina Anastasiia Mikhailovna

Radchenko Aleksandra Igorevna

Ekimova Natalia Viktorovna

Dates

2024-10-21Published

2023-12-25Filed