FIELD: medicine.
SUBSTANCE: invention refers to medicine, particularly to experimental pharmacology and genetic technologies. Described method is as follows. In dysferlin-deficient mice B6.A/J-Dysfprmd there is a marked increase in the duration of swimming with a load after a single introduction of a preparation based on adeno-associated virus of serotype 9 in dose of 1*1012 units of virus with the DYSF gene in amount of 50 mcl in the following muscles of both hind limbs: m. vastus lateralis, m. tibialis anterior, m. gastrocnemius lateralis (per animal in total 300 mcl) in test "Forced swimming with load" in 3 months after introduction of AAV9-DYSF-DV.
EFFECT: invention can be used to improve physical performance.
1 cl, 1 dwg, 3 tbl, 1 ex
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Authors
Dates
2024-10-21—Published
2023-12-25—Filed