METHODS OF TREATING ALLERGY AND INTENSIFYING ALLERGEN-SPECIFIC IMMUNOTHERAPY BY ADMINISTERING IL-4R ANTAGONIST Russian patent published in 2025 - IPC A61K39/395 A61K38/20 A61K45/06 A61P37/08 

FIELD: medicine; pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry, namely to a method for increasing efficacy and/or tolerance of a subcutaneous immunotherapy regimen. Method of increasing the efficacy and/or tolerance of a subcutaneous herb allergen-specific immunotherapy (SCIT) regimen in a patient suffering grass allergy involves administering an initial dose of 600 mg to the patient and one or more secondary doses of 300 mg of the interleukin-4 receptor (IL-4R) antagonist in combination with the SCIT regimen, wherein the initial dose of the IL-4R antagonist is administered to subject 1–14 days before the beginning of the SCIT regimen, and wherein the IL-4R antagonist is an anti-IL-4R antibody or an antigen-binding fragment thereof, which comprises heavy chain variable region (HCVR) complementarity determining regions (HCDR), comprising the amino acid sequence SEQ ID NO: 1, and light chain variable region (LCVR) complementarity determining region (LCVR) containing the amino acid sequence SEQ ID NO: 2.

EFFECT: use of the invention provides improved efficacy and/or tolerance of the allergen-specific immunotherapy regimens in a subject suffering from grass allergy.

23 cl, 7 tbl, 1 ex