METHODS OF TREATMENT OR PREVENTION OF ASTHMA THROUGH ADMINISTRATION OF IL-4R ANTAGONIST Russian patent published in 2023 - IPC A61K39/00 A61P11/06 

FIELD: medicine.

SUBSTANCE: group of inventions relates to a method of reducing the incidence of one or more asthma exacerbations and to a method of reducing the incidence of asthma exacerbations or improving one or more asthma-related parameters. A method of reducing the incidence of one or more asthma exacerbations in a subject suffering from moderate-to-severe eosinophilic asthma is proposed, comprising administering to the subject an antibody or antigen-binding fragment thereof that specifically binds to the interleukin 4 receptor (IL-4R), where the said antibody or antigen-binding fragment contains three sequences of heavy chain complementarity determining regions (HCDRs) containing SEQ ID NOs: 148, 150 and 152, and three light chain complementarity determining regions (LCDR) sequences containing SEQ ID NO: 156, 158, and 160, and wherein the said antibody or antigen-binding fragment thereof is an additional maintenance treatment. Also a method is provided for reduction of the incidence of asthma exacerbations or improving one or more asthma-related parameters in a subject suffering from moderate-to-severe eosinophilic asthma, comprising sequentially administering to the subject a single initial dose of an antibody or antigen-binding fragment thereof that specifically binds to the interleukin 4 receptor (IL-4R), followed by one or more secondary doses of the said antibody or antigen-binding fragment thereof, wherein the said antibody or antigen-binding fragment thereof contains three heavy chain complementarity determining regions (HCDR) sequences containing SEQ ID NOs: 148, 150 and 152, and three light chain complementarity determining regions (LCDR) sequences containing SEQ ID NO: 156, 158, and 160, and wherein the said antibody or antigen-binding fragment thereof is an additional maintenance treatment.

EFFECT: above group of inventions provide targeted therapy methods for treating or preventing asthma.

3 cl, 31 dwg, 13 tbl, 4 ex