FIELD: biotechnology.
SUBSTANCE: present invention relates to biotechnology and can be used in medicine. Invention discloses an anticancer conjugate based on human serum albumin with structural formula HSA-Cy5-HcyCo(B9C2H11)2-MMAE or HSA-Cy5-HcyCo(B9C2H11)2-MMAF, having in its composition a contrast agent and a boron-containing agent, as well as a chemotherapeutic agent (MMAE or MMAF) attached to the HSA through a linker, which is cleaved in the lysosome of the tumour cell.
EFFECT: invention can be used in diagnosing and treating human glioblastomas.
1 cl, 4 dwg, 1 tbl, 4 ex
| Title | Year | Author | Number |
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|
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| CONJUGATE OF A FLUORESCENT DYE WITH A PEPTIDE SUBSTANCE WHICH CONTAINS A PSMA-BINDING LIGAND BASED ON A UREA DERIVATIVE FOR VISUALIZING CELLS EXPRESSING PSMA, A METHOD FOR PRODUCTION THEREOF AND USE THEREOF | 2019 |
|
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| ANTI-CD79b ANTIBODIES AND IMMUNOCONJUGATES AND METHODS FOR USING THEM | 2008 |
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RU2553566C2 |
| ANTIBODY-DRUG CONJUGATES WITH HIGH DRUG LOADING | 2015 |
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RU2674979C2 |
