METHOD OF OBTAINING AN ANTITUMOR CONGRUIT ON THE BASIS OF HUMAN SERUM ALBUMIN CONTAINING THERAPEUTIC AND CONTRAST AGENTS Russian patent published in 2018 - IPC A61K31/704 A61K47/42 A61P35/00 

FIELD: medicine; pharmacology.

SUBSTANCE: invention relates to pharmacology and medical diagnostics. Antitumor conjugate is obtained by successive modifications of human serum albumin (HSA), which sequentially is first treated with an excess maleimides derived daunomycin, then the obtained intermediate HSA conjugate with daunomycin is treated with excess N-(2,3,5-trifluoro-4,6-bis(trifluoromethyl)phenyl) thiolactone homocysteine in dimethylsulfoxide, and the intermediate conjugate obtained in the previous step is treated with an excess of the meleimide derivative of trifluorothymidine, treatment of HSA and intermediate conjugates with a suitable reagent incubate the reaction mixture at 37 °C for 18 hours, followed by separation of the excess of low molecular weight components of the reaction mixture and drying of the purified high molecular weight fraction.

EFFECT: invention provides the possibility of producing a conjugate of a given structure comprising two therapeutic and contrast agents, as well as simplifying the method and increasing the yield of the target conjugate.

2 cl, 1 ex, 1 dwg