NEW APPLICATIONS Russian patent published in 2025 - IPC A61K31/519 A61P25/14 A61P25/16 C07D487/12 C07D487/14 

FIELD: medicine.

SUBSTANCE: invention refers to medicine and concerns diseases or disorders associated with the intracellular pathway of the dopamine D1 receptor in patients currently undergoing treatment with known dopamine replacement therapies. Disclosed method of mitigating side effect of dopamine replacement therapy involves administering a pharmaceutically effective amount of a PDE1 inhibitor to a subject in need thereof, wherein the side effect of the dopamine replacement therapy is a motor fluctuation, and wherein the PDE1 inhibitor is a compound selected from compounds of formula I, compounds of formula II and compounds of formula III, in free form or in form of a salt.

EFFECT: administering said PDE1 inhibitor to a patient suffering such a disease or disorder enhances the positive effects of the dopamine replacement therapy, thereby alleviating such a negative side effect as motor fluctuation, which is usually associated with such therapies.

16 cl, 4 dwg, 1 ex