FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing a Form I anhydrate crystal of a compound of formula (I), characterized by that it has a powder X-ray diffraction spectrum containing characteristic peaks at diffraction angles (2θ) 15.8° ± 0.2°, 19.4° ± 0.2°, 21.7° ± 0.2°, 23.9° ± 0.2° and 25.4° ± 0.2°; or diffraction angles (2θ) 7.9° ± 0.2°, 9.3° ± 0.2°, 12.9° ± 0.2°, 15.8° ± 0.2° and 19.4° ± 0.2°. Method is carried out by heating a solution of a compound of formula (I) in 2-propanol with water and methanol to 50 °C subsequent addition of water, cooling and filtration of the obtained precipitate.
EFFECT: crystalline form of the anhydrate of the compound of formula (I), having properties of stability, low coefficient of compressibility (%) of the crystal and favorable fluidity of the crystal.
3 cl, 13 dwg, 18 tbl, 11 ex
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