MULTIFUNCTIONAL QUINOLINE DERIVATIVES AS ANTINEURODEGENERATIVE AGENTS Russian patent published in 2018 - IPC C07D215/26 C07D401/06 C07D401/12 A61K31/47 A61K31/4709 A61K31/496 A61P25/28 

FIELD: chemistry.

SUBSTANCE: invention relates to a hydroxy-derived quinoline of the formula (I)

or to a pharmaceutically acceptable salt thereof, (I) wherein R¹ is hydrogen, (C₁-C₃)alkyl, (C₁)alkylene(C₃)cycloalkyl, (C₁)haloalkyl or (C₁)alkylene(C₆)aryl; R² is hydrogen or halogen; R³ is hydrogen, halogen, (C₁)alkyl or (C₁)alkoxy; R⁴ is hydrogen, halogen, (C₁)alkyl, (C₁)alkoxy or (C₁)haloalkyl; R⁵ and R⁶ are hydrogen; and R⁷ is (C₉-C₁₅)alkanol, (C₁)alkylenepiperazinyl(C₁-C₂)alkanol, (C₁-C₈)alkylenepiperazinyl (C₁-C₂)alkyl, (C₁₀-C₁₃)alkylene OCOCH₃, (C₁)alkylene(C₁)alkylamino(C₃)alkynyl, (C₁)alkyleneamino(C₈)alkanol or (C₁)alkyleneamino(C₆)alkanol(C₁)alkylene(8-methoxyquinolin-2-yl); or (II), where R¹, R², R³, R⁴ and R⁶ each is as described in (I) above; R⁵ is (C₁₁-C₁₂)alkanol, and R⁷ is hydrogen. The invention also relates to a pharmaceutical composition based on the formula (I) compounds, a method for treatment of Alzheimer's disease, traumatic brain injury and/or damage to the spinal cord and a method for improvement of the ability of learning and/or memory in a patient suffering from Alzheimer's disease, based on the formula (I) compound.

EFFECT: new hydroxy derivatives of quinoline have been obtained that have useful biological properties.

13 cl, 13 dwg, 9 ex