(6S,9AS)-N-BENZYL-6-[(4-HYDROXYPHENYL)METHYL]-4,7-DIOXO-8-({6-[3-(PIPERAZIN-1-YL)AZETHYDIN-1-YL]PYRIDINE-2-YL}METHYL)-2-(PROP-2-EN-1-YL)-OCTAHYDRO-1H-PYRASINO[2,1-C][1,2,4]TRIAZINE-1-CARBOXAMIDE COMPOUND Russian patent published in 2018 - IPC C07D487/04 C07F9/09 A61K31/53 A61K31/661 A61P35/00 

Abstract RU 2669805 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a compound represented by the formula (1) or a pharmaceutically acceptable salt thereof. In the formula (1) R1 is C1-6 alkyl group; R2 and R3 are the same or different from each other and each represents a hydrogen atom or a C1-6 alkyl group; X2, X3 and X4 are the same or different from each other and each represents a hydrogen atom or a halogen atom; and X5 represents a hydrogen atom or -P(=O)(OH)2. Invention also relates to compounds selected from the group, to individual compounds and to a pharmaceutical composition.

.

EFFECT: new compounds of formula (1) having the properties of a Wnt signaling inhibitor have been obtained.

17 cl, 3 dwg, 6 tbl, 29 ex

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RU 2 669 805 C2

Authors

Inoue Satosi

Yamamoto Yudzi

Iso Kentaro

Dates

2018-10-16Published

2014-12-22Filed