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1 340 060

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Application

3947452/04, 1985-06-26

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Actual filing date

1985-06-26

(45)

Published

1994-11-15

(72)

Inventor

Andrejchikov Ju.S.Syropjatov B.Ja.Koz'Minykh E.N.Koz'Minykh V.O.

N-NITROBENZOYLHYDRAZIDE OF MALEIC ACID SHOWING ANTIAGGREGATING ACTIVITY WITH RELATION TO BLOOD PLASMA PLATELATES Russian patent published in 1994 - IPC

Abstract SU 1340060 A1

FIELD: organic chemistry. SUBSTANCE: new substances showing enhanced activity are synthesized from nitrobenzoic acid hydrazide and maleic anhydride in the medium of acetonitrile. Yield is 91%, m. p. is 179-180 C (for ortho-nitro-derivative) and 96% and m. p. is 195-196 C (for para-nitro-derivative). Synthesized compounds show enhanced activity and less toxicity as compared with that of maleic acid N-benzoylhydrazide. Platelet aggregation degree for synthesized substances is 50%, LD50 = 590-540 mg/kg against 65% and 270 mg/kg at the dose 27 mg/kg. EFFECT: enhanced activity of synthesized compounds. 1 tbl

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SU 1 340 060 A1

Authors

Andrejchikov Ju.S.

Syropjatov B.Ja.

Koz'Minykh E.N.

Koz'Minykh V.O.

Dates

1994-11-15—Published

1985-06-26—Filed

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