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1 540 240

(13)

A1

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IPC

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Application

4424109/04, 1988-05-16

(22)

Actual filing date

1988-05-16

(45)

Published

1995-09-10

(72)

Inventor

Paronikjan E.G.Sirakanjan S.N.Noravjan A.S.Paronikjan R.G.Akopjan N.E.

5-SUBSTITUTED 1-AMINO-8,9- DIHYDRO-8,8- DIMETHYL-3,6H- PYRAZOLO-[3,4-B]- PYRANO-[4',3'-D]- PYRIDINE OR THEIR HYDROCHLORIDES SHOWING ANTICONVULSANT ACTIVITY Russian patent published in 1995 - IPC

Abstract SU 1540240 A1

FIELD: heterocyclic compounds. SUBSTANCE: product: 5-substituted 1-amino-8,9- dihydro-8,8- dimethyl-3,6H- pyrazolo-[3,4-b] pyrano- -[4',3'-d] pyridines of the formula where a) R C2H5; b) R - iso-C3H7; c) R C6H5, or their hydrochlorides. Synthesis is carried out by reaction of 2,2-dimethyl-4-(N-morpholino)-2,3-dihydro-6H-pyran with carboxylic acid chloroanhydride, cyclization of prepared 5-acyl-2,2-dimethyltetrahydropyran-4-ones with cyanoacetamide to 1-alkyl(aryl)-6,6-dimethyl-5,6-dihydro-3-oxo-4-cyano-8H-pyrano-[3,4-c] -pyridines, conversion of the latters to the corresponding chloroderivatives and their cyclization with hydrazine hydrate followed by conversion to hydrochlorides. EFFECT: improved method of synthesis of compounds indicated above. 4 tbl

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SU 1 540 240 A1

Authors

Paronikjan E.G.

Sirakanjan S.N.

Noravjan A.S.

Paronikjan R.G.

Akopjan N.E.

Dates

1995-09-10—Published

1988-05-16—Filed

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