FIELD: organic chemistry. SUBSTANCE: product: 1-amino-8,9-dihydro-5-morpholino-7,7,8-trimethyl-2-ethoxycarb- onyl-6H-thieno-[2,3-c] [2,7] -naphthiridine or its dihydrochloride. Synthesis is carried out by reaction of 5,6-dihydro-3-mercapto-1-morpholino-6,6,7-trimethyl-4-cyano-8- H-[2,7]-naphthiridine with ethylchloroacetate followed by cyclization with sodium ethylate and conversion if necessary to dihydrochloride. Yield is 71.25% m. p. is 230-231 C, empirical formula is C20N28N4O3S.. New compounds show increased activity and lowered toxicity as compared with ethyleneimine. On the strain of salmonella TA 1950 dihydrochloride is metabolized to the more active compound which induces mutations by 117 times more than ethyleneimine. Synthesized compounds can be used in selection of mutant strains of microorganisms for microbiological production. EFFECT: increased activity, decreased toxicity. 4 tbl
| Title |
Year |
Author |
Number |
| 1-AMINO-8,9-DIHYDRO-5,8,8-TRIMETHYL-3,6H-PYRAZOLO(3,4-b)THIOP- YRANO(4,3-D)PYRIDINE OR ITS HYDROCHLORIDE SHOWING ANTICONVULSANT ACTIVITY |
1989 |
- Paronikjan E.G.
- Sirakanjan S.N.
- Noravjan A.S.
- Paronikjan R.G.
- Akopjan N.E.
|
SU1626648A1 |
| 3-AMINO -2- CARBETHOXY -5,5- DIMETHYL-8- (N-MORPHOLINO) -4,5-DIHYDRO -7H-PYRANO (4,3-D)T IENO (2,3-B)PYRIDINE POSSESSING ANTIMUTAGEN ACTIVITY |
1984 |
- Paronikjan E.G.
- Mirzojan G.V.
- Noravjan A.S.
- Vartanjan S.A.
- Akopjan L.G.
- Paronikjan G.M.
|
SU1184244A1 |
| 5-SUBSTITUTED 1-AMINO-8,9- DIHYDRO-8,8- DIMETHYL-3,6H- PYRAZOLO-[3,4-B]- PYRANO-[4',3'-D]- PYRIDINE OR THEIR HYDROCHLORIDES SHOWING ANTICONVULSANT ACTIVITY |
1988 |
- Paronikjan E.G.
- Sirakanjan S.N.
- Noravjan A.S.
- Paronikjan R.G.
- Akopjan N.E.
|
SU1540240A1 |
| 1,2,4-TRIAZOLO- [1,5-A] -8,8-DEMETHYL -8,9- DIHYDRO-10- CYAN-6H- PYRANO- [4′,3′:4,5] -PYRIDINE-5 (1H)-TION |
1983 |
- Paronikjan E.G.
- Mirzojan G.V.
- Noravjan A.S.
- Vartanjan S.A.
|
SU1187440A1 |
| 5-MORPHOLINO- 2,2,10-TRIMETHYL- 8-PHENYL- 1,2-DIHYDRO-4H-PYRANO- - [4',3':4,5]- PYRIDO-[2,3-B]- THIENO-[3,2-B]- PYRIDINE-9-CARBOXYLIC ACID |
1986 |
- Paronikjan E.G.
- Noravjan A.S.
- Mirzojan G.V.
- Vartanjan S.A.
- Paronikjan R.G.
- Akopjan N.E.
|
SU1417446A1 |
| DERIVATIVES OF 2,2-DIMETHYL-1,2-DIHYDRO-4H-PYRANO-[4,3D]-FURO-[2,3-B]-PYRIDINE SHOWING ANTITUMOR ACTIVITY |
1990 |
- Paronikjan E.G.
- Oganesjan A.Kh.
- Noravjan A.S.
- Arsenjan F.G.
- Stepanjan G.M.
- Garibdzhanjan B.T.
|
SU1786804A1 |
| 1,2,4-TRIAZOLO{4,3-C]-10,10-DIMETHYL-8,10-DIHYDRO-11H-PYRANO [4′, 3′:4,5] PYRROLO [2,3-D] PYRIMIDINE |
1983 |
- Noravjan A.S.
- Paronikjan E.G.
- Mirzojan G.V.
- Vartanjan S.A.
|
SU1116712A1 |
| SUBSTITUTED 1,2-DIHYDRO-5-MORPHOLINO-4H-PYRANO-[4′,3′:4,5]-PYRIDO-[2,3-B]-THIENO-[3,2-D]-PYRIMIDINE-8(9H)-ONE OR -[9,11]-OXAZINE-8-ONE SHOWING ANTIBACTERIAL EFFECT |
1985 |
- Paronikjan E.G.
- Noravjan A.S.
- Mirzojan G.V.
- Vartanjan S.A.
- Ter-Zakharjan Ju.Z.
- Oganjan Sh.G.
|
SU1282510A1 |
| 2,2-DIMETHYL-1,2-DIHYDRO-5-(N-MORPHOLINE)-8-CHLOR OR PHENYLHYDRAZINO-4H-PIRANO[4′,3′:4,5]PYRIDO[2,3-B]THIENO[3,2-D]-9,10,11-TRIAZINES HAVING ANTITUMOR ACTION |
1988 |
- Paronikjan E.G.
- Mirzojan G.V.
- Noravjan A.S.
- Arsenjan F.G.
- Stepanjan G.M.
- Garibdzhanjan B.T.
|
SU1570274A1 |
| 4-AMINO-6,6-DIMETHYL-5, 6-DIHYDRO-8H-PYRANO /4′,3′:4,5/ PYROLLO [2,3-D]PYRIMIDINE |
1982 |
- Noravjan A.S.
- Paronikjan E.G.
- Mirzojan G.V.
- Vartanjan S.A.
|
SU1088331A1 |
