N-{4-[BIS-(2- CHLOROETHYL)- AMINO]- PHENYLACETYL} -2-(4-FLUOROPHENYL)-DL-ALANINE HAVING ANTITUMORAL EFFECT Russian patent published in 1994 - IPC

Abstract SU 1568480 A1

FIELD: medicine. SUBSTANCE: synthesis is carried out by reaction 2-(fluorophenyl)-DL-alanine with 4-[bis-(2- chloroethyl)-amino] -phenylacetylchloride in the presence of sodium hydroxide. The process takes place in the medium of aqueous dioxane at temperature (-5)- (-20) C. Desired product has empirical formula C2H23Cl2FN2O3, its yield is 56.4% , its melting point is 129-131 C. EFFECT: produces novel compound having improved efficiency. 2 tbl

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SU 1 568 480 A1

Authors

Kljukene R.B.

Marozene A.V.

Karpavichjus K.I.

Shimkjavichene V.J.

Laukajtis V.A.

Valavichene Ja.V.

Ljutkene R.G.

Dates

1994-01-30Published

1988-08-18Filed