2-[3-(2-CHLOROETHYL)-3-NITROSOUREIDO]-1,3-PROPANEDIOL SHOWING ANTITUMOR ACTIVITY Russian patent published in 1996 - IPC

Abstract RU 2068843 C1

FIELD: organic chemistry. SUBSTANCE: product: 2-[3-(2-chloroethyl)-3-nitrosoureido]-1,3-propanediol of the formula ClCH2CH2(N=0) N(O) CNHCH(CH2OH)2. Reagent 1: 2-chloroethylisocyanate. Reagent 2: 2-amino-1,3-propanediol. Reaction condition: reagent 1 is treated with reagent 2 and 2-[3-(2-chloroethyl)-ureido]-1,3-propanediol is synthesized which is subjected for nitrosation in 50% acetic acid. Synthesized end product is used in medicine as antitumor agent. EFFECT: improved method of synthesis. 7 tbl

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Authors

Kon'Kov S.A.

Stukov A.N.

Kil'Maeva N.E.

Reztsova V.V.

Krylova I.M.

Shenberg N.N.

Ivin B.A.

Filov V.A.

Dates

1996-11-10Published

1992-08-06Filed