N-PHOSPHORYLATED DERIVATIVES OF 3-β- PHENYLISOPROPYLSYDNONEIMINE SHOWING ANTITUMOR ACTIVITY Russian patent published in 1995 - IPC

Abstract RU 2036914 C1

FIELD: organic chemistry. SUBSTANCE: products: N6-(methoxymethylphosphonyl)-3-β-phenylisopropylsydnoneimi- ne, empirical formula is C13H18N3O3P, yield is 79%, m. p. is 84-86 C; N6-(dimethoxyphosphoryl)-3-β-phenylisopropylsydnoneimine, empirical formula is C13H18N3O4P, yield is 67%, m. p. is 45.5-47.5 C; N6-(bis-dimethylamidophosphoryl)-3-β-phenylisopropylsydnon- eimine, empirical formula is C15H24N5O2P, yield is 83%, m. p. is 98-99 C; 3-β-phenylisopropylsydnoneimido-b-phenethylamidophosphate potassium, empirical formula is C19H22N4O3PK, yield is 70%, m. p. is 201 C (with decomposition); 3-β-phenylisopropylsydnoneimidomorpholinophosphate potassium, empirical formula is C15H20N4O4PK, yield is 60%, m. p. is 186-189 C; N6-(bis-ethyleneimidophosphoryl)-3-β-phenylisopropylsydnon- eimide, empirical formula is C15H20N5O2P, yield is 88%, m. p. is 90-92 C; 3-β-phenylisopropylsydnoneimidothiophosphoric acid disodium salt monohydrate, empirical formula is C11H12N3O3PSNa2·H2O, yield is 87%, m. p. is 238 C (with decomposition); 3-β-phenylisopropylsydnoneimido-b-oxyethylphosphate sodium monohydrate, empirical formula is C13H17N3O4PSNa·H2O, yield is 56%, m. p. is 68-69 C; N6-(dimethoxythiophosphoryl)-3-β-phenylisopropylsydnoneimi- ne, empirical formula is C13H18N3O3PS, yield is 96%, m. p. is 53-55 C. EFFECT: improved method of synthesis. 6 tbl

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RU 2 036 914 C1

Authors

Sokolova A.S.

Borisov E.V.

Vasil'Ev A.V.

Parshin V.A.

Zabrodin V.B.

Safonova T.S.

Dates

1995-06-09Published

1991-06-27Filed