FIELD: organic chemistry, heterocyclic compounds. SUBSTANCE: product: 3-(benzylaminocarbonylmethylthio)-1,2,4-triazino-[5,6-b] -indole. Synthesis is carried out by reaction of 3-mercapto-1,2,4-triazine-[5,6-b]-indole in NaOH with N-benzylchloroacetamide. Yield is 72%, LD50 = 874 mg/kg. Preliminary administrated compound increases physical endurance of rats and at the late time it exceeds the effect of the known compound. EFFECT: enhanced activity of compound. 1 tbl
| Title |
Year |
Author |
Number |
| 3-(2-DIETHYLAMINOETHYLTHIO)-1,2,4-TRIAZINO-[5,6-B]-INDOLYL-5- ACETAMIDE HYDROCHLORIDE ACCELERATING RECOVERY PROCESS AFTER PHYSICAL LOADING |
1989 |
- Tomchin A.B.
- Spivakova R.P.
- Smirnov A.V.
|
SU1623156A1 |
| 3-(3-MORPHOLINOPROPYLTHIO)-1,2,4-TRIAZINO-[5,6-B]-INDOLE HYDROCHLORIDE RECOVERING PHYSICAL ENDURANCE AFTER POISONING WITH ORGANOPHOSPHORUS PESTICIDE |
1988 |
- Tomchin A.B.
- Zhukova T.I.
- Kuznetsova T.A.
- Kalinina I.B.
- Spivakova R.P.
- Tonkopij D.V.
- Smirnov A.V.
|
SU1584352A1 |
| ETHYL ESTER OF 1,2,4-TRIAZINO-(5,6-B)INDOLYL-3-THIOGLYCOLIC ACID IMPROVING PHYSICAL RESISTANCE AND RESISTANCE OF ORGANISM AGAINST HYPOXIA |
1984 |
- Tomchin A.B.
- Khromenkova Z.A.
- Vinogradov V.M.
- Spivakova R.P.
- Sumina Eh.N.
- Basieva T.S.
|
SU1233460A1 |
| 8-BROMO-3-(2-DIETHYLAMINOETHYLTHIO)-1,2,4-TRIAZINO(5,6-B)INDOLE WHICH ACCELERATES PROCESSES OF REDUCTION AFTER PHYSICAL LOAD AND PROLONGED STRESS |
1984 |
- Tomchin A.B.
- Vinogradov V.M.
- Katkov V.F.
- Spivakova R.P.
- Krylova I.M.
- Katkova E.B.
|
SU1223608A1 |
| N-(2-N-PIPERIDINOETHYL) AMIDE OF 1,2,4-TRIAZINO[5,6-B]INDOLYL-3-THIOGLYCOLIC ACIDS WHICH IMPROVES PHYSICAL RESISTANCE AND HAS PROTECTING ACTIVITY AGAINST STRESS |
1984 |
- Tomchin A.B.
- Vinogradov V.M.
- Katkov V.F.
- Spivakova R.P.
- Sumina Eh.N.
- Katkova E.B.
|
SU1210414A1 |
| DIHYDROCHLORIDE OF MONOHYDRATE OF 8-BROMO-3-(2-MORPHOLINOETHYLTHIO)-1,2,4-TRIAZINO/5,6-B/INDOLE HAVING PROTECTING ACTIVITY AGAINST STRESS AND INCREASING PHYSICAL RESISTANCE |
1984 |
- Tomchin A.B.
- Vinogradov V.M.
- Katkov V.F.
- Spivakova R.P.
- Smirnov A.V.
- Katkova E.B.
- Lozinskij M.O.
- Bobkov Ju.G.
|
SU1220301A1 |
| HYDROCHLORIDE OF 3-(2-DIMETHYLAMINOETHYLTHIO)-9-METHYL-1,2,4-TRIAZINO(6,5-B)INDOLE WHICH INCREASES PHYSICAL RESISTANCE |
1981 |
- Tomchin A.B.
- Vinogradov V.M.
- Spivakova R.P.
- Basieva T.S.
|
SU1061424A1 |
| 8-AMINO-3-(2-MORPHOLINOETHYLTHIO)-1,2,4-TRIAZINO-[5,6-B]-INDOLE HYDROCHLORIDE PROTECTING LIVER AGAINST CARBON TETRACHLORIDE INTOXICATION AND PROCESS ACCELERATING AFTER PHYSICAL LOADING |
1991 |
- Tomchin A.B.
- Smirnov A.V.
- Gajvoronskaja V.V.
- Okovityj S.V.
- Spivakova R.P.
|
SU1809608A1 |
| AMIDE OF (1,2,4-TRIAZINO[5,6-B]INDOLYL-3-THIO)ACETIC ACID WHICH ACCELERATES PROCESSES OF REDUCTION AFTER PHYSICAL LOAD AND HAS ACTIVITY AGAINST HYPOXIA |
1987 |
- Tomchin A.B.
- Zhukova T.I.
- Kuznetsova T.A.
- Vinogradov V.M.
- Spivakova R.P.
- Urjupov O.Ju.
- Kostycheva M.V.
|
SU1487413A1 |
| 3-(2-MORPHOLINOETHYLTHIO)-1,2,4-TRIAZINO-[5,6-B]-INDOLYL-5- ACETAMIDE DIHYDROCHLORIDE ACCELERATING RECOVERY PROCESS AFTER PHYSICAL LOADING, ENHANCING RESISTANCE TO HYPERTHERMIA AND SHOWING ANTIHYPOXIC ACTIVITY |
1987 |
- Tomchin A.B.
- Vinogradov V.M.
- Spivakova R.P.
- Tonkopij D.V.
- Katkov V.F.
- Sumina Eh.N.
- Katkova E.B.
- Urjupov O.Ju.
- Kostycheva M.V.
|
SU1498021A1 |
