FIELD: organic chemistry, heterocyclic compounds. SUBSTANCE: product: 3-(2-morpholinoethylthio)-1,2,4-triazino-[5,6-b] -indolyl-5-acetamide dihydrochloride. Synthesis is carried out by reaction of 3-(2-morpholinoethylthio)-1,2,4-triazino-[5,6-b] -indole sodium salt and formamide. Yield is 80.6%, empirical formula is C17H22Cl2N6O2S, m. p. is 186 C. Protection coefficient of new compound against hypoxia is 1.4, protection degree of animals against hyperthermia is 53% as compared with 30% for bemithyl, recovery degree after physical loading is increased by 142% as compared with control. EFFECT: new compound showing enhanced activity. 4 tbl
| Title |
Year |
Author |
Number |
| 3-(2-DIETHYLAMINOETHYLTHIO)-1,2,4-TRIAZINO-[5,6-B]-INDOLYL-5- ACETAMIDE HYDROCHLORIDE ACCELERATING RECOVERY PROCESS AFTER PHYSICAL LOADING |
1989 |
- Tomchin A.B.
- Spivakova R.P.
- Smirnov A.V.
|
SU1623156A1 |
| 3-(2-DIMETHYLAMINOETHYLTHIO)-8-METHOXY-1,2,4-TRIAZINO-[5,6-B]- INDOLE DIHYDROCHLORIDE ENHANCING RESISTANCE TO HYPERTHERMIA |
1988 |
- Tomchin A.B.
- Katkov V.F.
- Sumina Eh.N.
- Katkova E.B.
- Krjukova L.M.
- Zelenin K.N.
|
SU1552605A1 |
| 8-AMINO-3- (2-DIETHYLAMINOETHYLTHIO) -1,2,4-TRIAZINO (5,6-B)- INDOL HYDROCHLORIDE ACCELERATING RECOVERY OF ENCEPHALON FUNCTIONS IN EARLY PERIOD AFTER ACUTE MICROWAVE THERMAL STRESS |
1990 |
- Tomchin A.B.
- Grechko A.T.
- Smirnov A.V.
|
SU1786803A1 |
| 8-METHYL-3-(2-MORPHOLINOETHYLTHIO)-5H-1,2,4-TRIAZINO[5,6-B]INDOLE DIHIDROCHLORIDE HYDRATE SHOWING CAPABILITY TO ACCELERATE RECOVERY OF CEREBRUM FUNCTION IN THE EARLY PERIOD AFTER ACUTE MICROWAVE THERMAL STRESS |
1990 |
- Grechko A.T.
- Tomchin A.B.
- Lomov O.P.
- Smirnov A.V.
|
RU1764298C |
| AMIDE OF (1,2,4-TRIAZINO[5,6-B]INDOLYL-3-THIO)ACETIC ACID WHICH ACCELERATES PROCESSES OF REDUCTION AFTER PHYSICAL LOAD AND HAS ACTIVITY AGAINST HYPOXIA |
1987 |
- Tomchin A.B.
- Zhukova T.I.
- Kuznetsova T.A.
- Vinogradov V.M.
- Spivakova R.P.
- Urjupov O.Ju.
- Kostycheva M.V.
|
SU1487413A1 |
| 8-BROMO-3-(2-DIETHYLAMINOETHYLTHIO)-1,2,4-TRIAZINO(5,6-B)INDOLE WHICH ACCELERATES PROCESSES OF REDUCTION AFTER PHYSICAL LOAD AND PROLONGED STRESS |
1984 |
- Tomchin A.B.
- Vinogradov V.M.
- Katkov V.F.
- Spivakova R.P.
- Krylova I.M.
- Katkova E.B.
|
SU1223608A1 |
| 3-(2-DIMETHYLAMINOETHYLTHIO)-8-METHYL-1,2,4-TRIAZINO-[5,6-B]- INDOLE DIHYDROCHLORIDE ENHANCING RESISTANCE TO HYPERTHERMIA |
1988 |
- Tomchin A.B.
- Katkov V.F.
- Sumina Eh.N.
- Katkova E.B.
- Kravchenko V.V.
|
SU1547279A1 |
| HYDROCHLORIDE OF 3-(2-DIPROPYLAMINOETHYLTHIO)-1,2,4-TRIAZINO[5,6-B)-INDOLE WHICH INCREASES RESISTANCE AGAINST HYPERTERMIA |
1987 |
- Tomchin A.B.
- Zhukova T.I.
- Kuznetsova T.A.
- Zvezdina N.S.
- Vinogradov V.M.
- Katkov V.F.
- Sumina Eh.N.
- Katkova E.B.
- Andreev V.B.
|
SU1483895A1 |
| 3-(2-DIETHYLAMINOETHYLAMINO)-1,2,4-TRIAZINO/6,5/INDOLE HYDROCHLORIDE HAVING ANTIINFLAMMATORY ACTIVITY AND INCREASING PHYSICAL RESISTANCE OF ORGANISM AGAINST HYPOXIA |
1981 |
- Tomchin A.B.
- Vinogradov V.M.
- Poskalenko A.N.
- Ponomareva M.M.
- Spivakova R.P.
- Basieva T.S.
|
SU1014249A1 |
| 8-AMINO-3-(2-MORPHOLINOETHYLTHIO)-1,2,4-TRIAZINO-[5,6-B]-INDOLE HYDROCHLORIDE PROTECTING LIVER AGAINST CARBON TETRACHLORIDE INTOXICATION AND PROCESS ACCELERATING AFTER PHYSICAL LOADING |
1991 |
- Tomchin A.B.
- Smirnov A.V.
- Gajvoronskaja V.V.
- Okovityj S.V.
- Spivakova R.P.
|
SU1809608A1 |
