STATISTIC COPOLYMERS AS LOW TOXIC COMPOUNDS HAVING PROLONGED HYPOTENSIVE ACTION AND METHOD FOR THEIR PRODUCTION Russian patent published in 1995 - IPC

FIELD: high molecular weight compounds. SUBSTANCE: desired copolymers having formula where m:n=1:1-1:3 are prepared by reaction of N-carboxyanhydride-Σ-Z-L--lysine with carbonate of dihydroxyphenyl alanine at molar ratio 1:1-3:1. The process is carried out in the presence of triethylamine, its quantity being equimolar to quantity of carbonate of dihydroxyphenyl alanine. Then products of reaction are treated by 4.0-6.0 N solution of HBr, the process takes place in glacial acetic acid within day at room temperature. ЛД₅₀, of desired copolymers is 37-140 mg/kg at dose 2-5 mg/kg. EFFECT: decreases toxicity of product. 3 cl, 3 tbl