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Application

4447077/04, 1988-06-22

(22)

Actual filing date

1988-06-22

(45)

Published

1996-11-20

(72)

Inventor

Praliev K.D.Ju V.K.Tarakov S.A.Utepbergenova R.K.Shin S.N.Nurakhova T.G.

1-(2-ETHOXYETHYL)-4-BENZOYLHYDROXYPIPERIDINE HYDROCHLORIDE SHOWING LOCAL ANESTHETIC ACTIVITY Russian patent published in 1996 - IPC

Abstract SU 1704414 A1

FIELD: organic chemistry, heterocyclic compounds. SUBSTANCE: product: 1-(2-ethoxyethyl)-4-benzoylhydroxypiperidine. Synthesis is carried out by reaction of 1-(2-ethoxyethyl)-4-hydroxypiperidine with benzoyl chloride in pyridine at room temperature for 24 hr. Yield is 67.5%, m. p. is 181-182 C, empirical formula is $$$. Total anesthesia period caused by 0.5% solution of new compound is 261.4 min, toxicity $$$ = 253 mg/kg (i. p.) as compared with 285.4 min and $$$ = 115 mg/kg for 1-(2-ethoxyethyl)-3e-methyl-4e-phenyl-4-acetoxypiperidine hydrochloride. Synthesized compound shows analgetic activity and can be used in medicine. EFFECT: enhanced activity of new compound. 4 tbl

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SU 1 704 414 A1

Authors

Praliev K.D.

Ju V.K.

Tarakov S.A.

Utepbergenova R.K.

Shin S.N.

Nurakhova T.G.

Dates

1996-11-20—Published

1988-06-22—Filed

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