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1 713 242

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A1

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IPC

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Application

4650940/04, 1989-02-13

(22)

Actual filing date

1989-02-13

(45)

Published

1994-11-15

(72)

Inventor

Tjukhteneva Z.I.Badovskaja L.A.Linchenko S.I.Bartashevich V.V.Ehgik'Jan A.L.Ljufi A.Ja.

4-HYDROXY-3-[N-(PHENACYL)BENZYLAMINO]-N-BENZYLBUTAMIDE HYDROBROMIC SALT SHOWING LOCAL ANESTHETIZING ACTIVITY Russian patent published in 1994 - IPC

Abstract SU 1713242 A1

FIELD: organic chemistry. SUBSTANCE: synthesis is carried out by reaction of phenacyl bromide with 3-benzylamino-4-hydroxy-N-benzylbutaneamides in the mixture of ethylacetate and chloroform. Yield is 57%, m. p. is 82-84 C, empirical formula is C26H24BrN2O3, effective dose is 10 mg/kg, duration effect is a longer time by 3.84-3.38 and 2.84-2.34 times as compared with that of novocaine and trimecaine, respectively (2% solution of anesthetizing agent is used), toxicity LD50290 against 154 mg/kg for novocaineamide. Anesthetizing effect of new agent is a longer time by 3.49-2.36 times as compared with that of novocaineamide. EFFECT: enhanced anesthetizing activity of synthesized compound. 7 tbl

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SU 1 713 242 A1

Authors

Tjukhteneva Z.I.

Badovskaja L.A.

Linchenko S.I.

Bartashevich V.V.

Ehgik'Jan A.L.

Ljufi A.Ja.

Dates

1994-11-15—Published

1989-02-13—Filed

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