FIELD: organic chemistry, heterocyclic compounds. SUBSTANCE: product: 1-(2-ethoxyethyl)-4-ethynyl-4-benzoylhydroxypiperidine. Synthesis is carried out by reaction of 1-(2-ethoxyethyl)-4-ethynyl-4-hydroxypiperidine with benzoyl chloride in pyridine at room temperature for 32 hr. Yield is 59.66%, m. p. is 173-174 C, empirical formula is $$$. Total anesthesia period caused by 0.5% solution of new compound is 316 min, toxicity $$$ = 335 mg/kg (i. p. ) as compared with 285.4 min and $$$ = 115 mg/kg for 1-(2-ethoxyethyl)-3e-methyl-4e-phenylethyl)-4-acetoxypiperidine. EFFECT: synthesis of new compound indicated above. 4 tbl
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| 1-(2-ETHOXYETHYL)-4-HYDROXYPIPERIDINE AS AN INTERMEDIATE COMPOUND FOR SYNTHESIS OF 1-(2-ETHOXYETHYL)-4-ACYLHYDROXYPIPERIDINE HYDROCHLORIDES SHOWING LOCAL ANESTHETIC ACTIVITY | 1988 |
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| 3-METHOXYCARBONYL-4-(2-PIPERIDINOETHYL)-2-ETHYLPYRAZOLO[1,5-A]BENZIMIDAZOLE HYDROCHLORIDE POSSESSING TOPICAL ANESTHETIC EFFECT | 2006 |
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| 1-(2-DIETHYLAMINOETHYL)-2-PHENYLIMIDAZO[1,2-A]BENZIMIDAZOLE DIHYDROCHLORIDE POSSESSING TOPICAL ANESTHETIC EFFECT AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF | 2006 |
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