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1 426 050

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A1

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IPC

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Application

4198371/04, 1986-12-15

(22)

Actual filing date

1986-12-15

(45)

Published

1994-06-15

(72)

Inventor

Zotova S.A.Stoljarchuk A.A.Stepanjuk G.I.Stepanjuk L.I.Terekhovskij A.I.

2-(3'-BROMO- 4'-METHOXYPHENYL)-3-CARBETHOXY-4-DIMETHYL -5-HYDROXYBENZOFURAN HYDROCHLORIDE SHOWING LOCAL ANESTHETIC ACTION Russian patent published in 1994 - IPC

Abstract SU 1426050 A1

FIELD: heterocyclic compounds. SUBSTANCE: product: 2-(3'-bromo-4'- methoxyphenyl)-3-carbethoxy-4- dimethyl-aminomethyl -5-hydroxybenzofuran. Synthesis is carried out by interaction of 2-(3'-bromo -4'-methoxyphenyl) -3- carbethoxy-5-hydroxybenzofuran with formaldehyde solution and dimethylamine hydrochloride at heating (100 C) in dimethyl- formamide. Yield is 57.8% , m. p. is 193-194 C, gross-formula is C21H23BrCINO5. Analgetic action of synthesized compound at the dose 5 mg/kg exceeds duration of analgetic effect of novocaine, trimecaine and lidocaine by 3.9, 2.2 and 1.9 times, respectively. Synthesized compounds can be used in medicine. EFFECT: enhanced effectiveness of synthesized compounds. 3 tbl

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SU 1 426 050 A1

Authors

Zotova S.A.

Stoljarchuk A.A.

Stepanjuk G.I.

Stepanjuk L.I.

Terekhovskij A.I.

Dates

1994-06-15—Published

1986-12-15—Filed

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