ARYLALIPHATIC AMINOAMIDES OF BENZOIC (SUBSTITUTED BENZOIC), CYCLOHEXANE- AND 1-ADAMANTANE CARBOXYLIC ACIDS SHOWING ANTI-ARRHYTHMIC, TOPICAL ANESTHETIC AND ANALGETIC ACTIVITY Russian patent published in 1999 - IPC

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention describes new biologically active compounds of the formula (I): C₂H₅(ROCNH)CH(CH₂)_n-R₁ being when R is C₆H₅ then R₁ is NC₄H₈O and n = 4, 6, 7; or R₁ is NC₅H₁₀ and n = 5; or R₁ is NC₆H₁₂ and n = 6; or R₁ is N(C₄H₉)₂ and n = 7; when R is C₆H₄Br-n then R₁ is N(C₂H₅)₂ and n = 4, 6, 7; or R₁ is NC₅H₁₀ and n = 6, 7; or R₁ is NC₄H₈O and n = 7; or R₁ is N(C₄H₉)₂ and n = 7; when R is C₆H₄Cl-n then R₁ is N(CH₃)₂ and n = 4; or R₁ is NC₄H₈O and n = 4; or R₁ is NC₅H₁₀ and n = 7; when R is C₆H₄NO₂-n then R₁ is N(C₂H₅)₂ and n = 7; when R is C₆H₄NO₂-m, then R₁ is N(C₂H₅)₂ and n = 4, 7; or R₁ is NC₄H₈O and n = 6, 7; or R₁ is NC₅H₁₀ and n = 6; when R is then R₁ is NC₄H₈O and n = 6; or R₁ is NC₅H₁₀ and n = 6; when R is C₆H₁₁ then R₁ is NC₄H₈O and n = 6; or R₁ is NC₅H₁₀ and n = 6; when R is 1-adamantyl then R₁ is NC₄H₈O and n = 6. Compounds show anti-arrhythmic, topical anesthetic and analgetic activities, they exhibit low toxicity and can be used in medicine. EFFECT: new bioactive compounds, low toxicity. 8 tbl, 27 ex