GLYCOPEPTIDE OF β-GLYCYRRHIZIC ACID WITH L-PHENYLALANINE METHYL ESTER SHOWING ANTIINFLAMMATORY AND ANTIULCEROUS ACTIVITIES Russian patent published in 1994 - IPC

Abstract SU 1777333 A1

FIELD: organic chemistry. SUBSTANCE: product: 1-0-[3b, 203β, 20β)-11,30-dioxo-30-(N-L-phenylalanine methyl ester)-olean-12-en-3yl] -2-0-b-D-oxo-6-deoxy-6-(N-L-phenylalanine methyl ester)glucopyranosyl]-a-D-6-oxo-6-deoxy-6-(N-L-phenylalanine methyl ester)glucopyranoside, gross-formula is C₁₂H₉₅N₃O₁₉, yield is 61%, [α]2D

⁰ = +30 rotation degree (c = 0.18, in CH₃OH). LD₅₀ = 135 mg/kg intraperitoneally. Reagent 1: glycyrrhizic acid. Reagent 2: L-phenylalanine methyl ester hydrochloride. Conditions: in the medium of dioxane in the presence of N-hydroxysuccinimide. Synthesized glycopeptide shows antiinflammatory and antiulcerous activities. EFFECT: improved method of synthesis. 4 tbl

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SU 1 777 333 A1

Authors

Baltina L.A.

Davydova V.A.

Zarudij F.A.

Lazareva D.N.

Tolstikov G.A.

Dates

1994-06-30—Published

1990-10-26—Filed