FIELD: organic chemistry. SUBSTANCE: product: 6-monoester of sucrose and o-chlorobenzoic acid, empirical formula is C19H25O12Cl, yield is 40% m. p. is 69-70 C, LD50 for rats is 620-670 mg/kg, for mice is 510-560 mg/kg. Inhibition percent of lymphosarcoma Pliss, carcinosarcoma Walker, sarcoma-37 is 66-81% Reagent 1: sucrose. Reagent 2: o-chlorobenzoic acid methyl ester. Reaction conditions: in the presence of K2CO3, in the medium of dimethylformamide, at 95-100 C, in atmosphere of inert gas. Product is isolated by column chromatography. Synthesized compound is used in medicine. EFFECT: improved method of synthesis, enhanced antitumor activity.
| Title |
Year |
Author |
Number |
| 5,7-O-BIS-(DIETHYLAMINOETHYL)-USNINIC ACID DITARTRATE SHOWING ANTITUMOR ACTIVITY |
1991 |
- Artamonova N.A.
- Nikonov G.K.
- Rakhimov K.D.
|
RU1782009C |
| SUCROSE AND CARATAVIC ACID MONOESTER SHOWING ANTIMALIGNANT ACTIVITY |
1987 |
- Artamonov A.F.
- Nikonov G.K.
- Bokaeva S.S.
- Edygenova A.K.
- Baramysova G.T.
|
SU1515652A1 |
| 4(5)-(3-NITRO-4-(3,3-DIMETHYLTRIAZENO-1)PHENYL)IMIDAZOLE POSSESSING ANTITUMOR ACTIVITY |
1982 |
- Iradjan M.A.
- Iradjan N.S.
- Stepanjan G.M.
- Arsenjan F.G.
- Garibdzhanjan B.T.
|
SU1074091A1 |
| DIHYDROCHLORIDE 1-(3-NITRO-4- METHOXYBENZENE)-2- [BIS-(2- CHLORETHYL) AMINOMETHYL]IMIDAZOLE POSSESSING ANTITUMOR ACTIVITY |
1981 |
- Iradjan M.A.
- Iradjan N.S.
- Stepanjan G.M.
- Garibdzhanjan B.T.
|
SU976654A1 |
| 1-(4-AMYLHYDROXY-3-NITROBENZYL)-2-METHYL-4-NITRO-5-[BIS-(2- CHLOROETHYL)-AMINOETHYL]-THIOIMIDAZOLE HYDROCHLORIDE SHOWING ANTITUMOR ACTIVITY |
1985 |
- Iradjan M.A.
- Iradjan N.S.
- Stepanjan G.M.
- Garibdzhanjan B.T.
|
SU1314627A1 |
| METHOD OF PRODUCING DIASTEREOMER OF N-[3-CHLORO-4-(2-CHLOROETHYLTHIO)-BUTANOYL]-L-PHENYLALANINE |
0 |
- Rastejkene L.P.
- Potsyute N.-B.K.
- Valavichene Ya.V.
- Karpavichyute A.K.
- Dembinskene I.A.
|
SU1329123A1 |
| ETHYL ESTER OF CIS-4-N-(N',N'-DIMETHYLAMIDO-N''-ETHYLENEIMIDOPHOSPHORYL)- AMINOCIC- LOCARBOXYLIC ACID HAVING ANTITUMORAL ACTIVITY |
1985 |
- Pikshilingajte Ju.-V.K.
- Kosykhova L.A.
- Ljutkene R.G.
- Karpavichjus K.I.
|
SU1282520A1 |
| COMPOUND POSSESSING ANTITUMOR ACTIVITY |
0 |
- Pogosyan Alina Arshalujsovna
- Nikogosyan Leva Lyudvikovich
- Kamalyan Karine Sergeevna
- Galstyan Donara Armenakovna
- Petanova Emiliya Vladimirovna
|
SU1826905A3 |
| 5-BENZIL-11,13-DIMETHHYL-2,8,12-TRIOXO-1,5,9-TRIAZACYCLO [9,3,1,1] HEXADECANE, POSSESSING ANTITUMOR ACTIVITY |
1985 |
- Agadzhanjan Ts.E.
- Arutjunjan G.L.
- Garibdzhanjan B.T.
- Chachojan A.A.
|
SU1285754A1 |
| BUTYRICC ACID COMPOSITION HAVING ANTITUMORAL ACTIVITY |
0 |
- Gireva R.N.
- Aleshina G.A.
- Maltseva L.F.
- Muratova G.P.
|
SU525311A1 |
