SUCROSE AND CARATAVIC ACID MONOESTER SHOWING ANTIMALIGNANT ACTIVITY Russian patent published in 1995 - IPC

Abstract SU 1515652 A1

FIELD: organic chemistry. SUBSTANCE: synthesis is carried out by treatment of caratavic acid methyl ester with sucrose solution in dimethylformamide in the presence of K₂CO₃ at 100-105 C, under pressure 100-120 mm mercury column in nitrogen medium for 15 h and methanol distillation off. Yield is 57%, m. p. is 112-114 C, empirical formula is C₃₆H₄₆O₁₅. New compound inhibits growth of sarcoma-180 by 75%, Pliss lymphosarcoma by 66-78%, AK-755 by 51%, ЛЛК by 56-42% and Walker carcinosarcoma by 53% at value LD₅₀ = 1900 mg/kg and minimal tolerant dose 250 mg/kg as compared with colchamine which does not effect on the sarcoma-180 and inhibits the growth of Pliss lymphosarcoma by 38% and Walker carcinisarcoma by 26%. EFFECT: increased antimalignant effectiveness of preparation.

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SU 1 515 652 A1

Authors

Artamonov A.F.

Nikonov G.K.

Bokaeva S.S.

Edygenova A.K.

Baramysova G.T.

Dates

1995-05-27—Published

1987-11-17—Filed