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Application

3919686/04, 1985-05-27

(22)

Actual filing date

1985-05-27

(45)

Published

1994-01-30

(72)

Inventor

Pikshilingajte Ju.-V.K.Kosykhova L.A.Ljutkene R.G.Karpavichjus K.I.

ETHYL ESTER OF CIS-4-N-(N',N'-DIMETHYLAMIDO-N''-ETHYLENEIMIDOPHOSPHORYL)- AMINOCIC- LOCARBOXYLIC ACID HAVING ANTITUMORAL ACTIVITY Russian patent published in 1994 - IPC

Abstract SU 1282520 A1

FIELD: organophosphorous compounds. SUBSTANCE: desired product is synthesized of N', N'-dimethylaminophosphoric acid dichloroanhydride and of ethyl ester of cis-4-aminocyclohexanecarboxylic acid. The process is carried out in the medium of absolute ether, it is followed by separation of precipitate. Then mixture of ethyleneimine and triethylamine is added into filtrate, reaction mixture being sustained at O C within 35 h. Precipitate is separated, filtrate is evaporated in vacuum, its chromatography being carried out. Desired product yield is 36% , its toxicity (ЛД50б is 307 mg/kg. EFFECT: increases activity. 2 tbl

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SU 1 282 520 A1

Authors

Pikshilingajte Ju.-V.K.

Kosykhova L.A.

Ljutkene R.G.

Karpavichjus K.I.

Dates

1994-01-30—Published

1985-05-27—Filed

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