METHOD OF N-ACYL DERIVATIVES OF 2′-DEOXYCYTIDINE SYNTHESIS Russian patent published in 1994 - IPC

Abstract RU 2007416 C1

FIELD: organic chemistry, derivatives of nucleotides. SUBSTANCE: product - N₄-acyl-derivatives of 2′-deoxycytidine of the general formula given in description. Yield is 90-94% . Reagent 1: 2′-deoxyxytidine. Reagent 2: acetic anhydride, benzoic anhydride, isobutyric anhydride. Reaction conditions: in the medium of N, N′-dimethylformamide, dimethylsulfoxide or trimethylphosphate at molar ratio deoxycytidine: anhydride: solvent = 1: (4-15): (26-40). Synthesized compounds are used as intermediates for synthesis of oligonucleotides. EFFECT: simplified method. 2 cl

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RU 2 007 416 C1

Authors

Bogachev V.S.

Khamzin M.G.

Dates

1994-02-15—Published

1991-03-05—Filed