FIELD: pharmaceutical industry. SUBSTANCE: method involves synthesis of derivatives of 3-propenylcepheme of the general formula I 
at the definitive meanings of R and A. Reagent 1: compound of the general formula II 
, where R means the groups: CH2F, or CH2CN, or CHF2, or CH2CF3; X - halogen atom, and amino- and/or carboxyl-group is protected with protecting groups, or its salt. Reagent 2: amine corresponding A, in which functional groups are protected with protecting groups, or its salt. EFFECT: improved method of synthesis. 10 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| CEPHEM COMPOUND OR ITS PHARMACEUTICALLY ACCEPTABLE SALT | 1992 |
|
RU2024530C1 |
| METHOD OF SYNTHESIS OF CEPHEM COMPOUNDS OR THEIR ACID-ADDITIVE SALTS | 1988 |
|
RU2017744C1 |
| DERIVATIVES OF THIOALKYLTHIOCEPHALOSPORIN OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, ANTIBACTERIAL COMPOSITION | 1991 |
|
RU2071963C1 |
| ANTIBIOTIC COMPOSITION | 1988 |
|
RU2029549C1 |
| METHOD OF PRODUCING COMPOUNDS OF CEPHEM OR THEIR SALTS | 0 |
|
SU1604160A3 |
| METHOD OF SYNTHESIS OF CEPHALOSPORIN DERIVATIVES OR THEIR SALTS | 1990 |
|
RU2024529C1 |
| SULFIDE DERIVATIVES | 1993 |
|
RU2060993C1 |
| CEPHEM COMPOUNDS AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS | 1992 |
|
RU2081874C1 |
| METHOD OF PREPARING CEPHEMIC COMPOUNDS OR THEIR SALTS | 0 |
|
SU1831484A3 |
| DERIVATIVES OF 3-AMMONIOPROPENYLCEPHEM-4-CARBOXYLATE WITH ANTIBACTERIAL ACTIVITY, DERIVATIVE OF 3-IODOPROPENYLCEPHEM AS AN INTERMEDIATE PRODUCT FOR THE SYNTHESIS OF DERIVATIVES OF 3-AMMONIOPROPENYLCEPHEM-4-CARBOXYLATE, 2-(5-TRITYLAMINO-1,2,4-THIADIAZOL-3-YL)-(Z)-2-FLUOROMETHOXYIMINOACETIC ACID AS AN INTERMEDIATE COMPOUND FOR T | 0 |
|
SU1705291A1 |
