METHOD OF SYNTHESIS OF ALKANESULFONANILIDE DERIVATIVES OR THEIRS PHARMACEUTICALLY ACCEPTABLE SALTS Russian patent published in 1994 - IPC

Abstract RU 2012557 C1

FIELD: organic chemistry. SUBSTANCE: products of the general formula Ar-X-C6H2 in the ring NHSO2R1 and R2 and R3, where Ar - a group C6H3(R4,R5), where R4 and R5 - hydrogen or halogen; X - , , , ; n = 0-2; R6 - halogen or lower alkyl; R1 - lower alkyl, halogen(lower)alkyl; R2 - lower alkanoyl, carbamoyl, mono- or di(lower) alkylcarbamoyl, cyano, carboxyl, hydroxy(lower) alkyl, amino(lower)alkyl or a group of the general formula , where R7 - lower alkoxy; R8 - lower alkyl; R3 - hydrogen or nitro-group. Reagent 1: compound of the general formula Ar-X-C6-H2-(NH2,R2R3, in the ring. Reagent 2: R1SO2OH. Synthesized compounds are used as antiinflammatory and analgetic drugs. EFFECT: improve method of synthesis of compound indicated above. 5 tbl

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Authors

Masaaki Matsuo[Jp]

Kiesi Tsudzi[Jp]

Nobukie Konisi[Jp]

Khirojuki Okumura[Jp]

Dates

1994-05-15Published

1988-05-27Filed