GUANIDINE DERIVATIVES, METHOD OF PREPARATION THEREOF, AND METHOD FOR INHIBITING Na/H EXCHANGE IN CELLS Russian patent published in 1999 - IPC

FIELD: pharmaceutical chemistry. SUBSTANCE: new guanidine derivatives with formula I: (I) are provided where Y is nitrogen or group C-R¹ (R¹ is hydrogen, lower alkyl, hydroxyl, etc.); R² is hydrogen, optionally substituted aryl, aryloxy group, etc.; R³ hydrogen, lower alkoxy, hydroxyl, etc.; Z nitrogen or C-R⁴ (R⁴ is hydrogen, halogen, hydroxyl, lower alkyl, etc. ); and W nitrogen or C-R¹² (R¹² is hydrogen) and their pharmaceutical acceptable salts. Compound of invention are useful as drugs in treatment and/or prophylactics of cardiac infarction or ischemic disease. Method of preparing these compounds is also provided. EFFECT: extended choice of cardiovascular medicines. 15 cl, 1 tbl, 34 ex