METHOD OF CATECHIN DERIVATIVES SYNTHESIS Russian patent published in 1994 - IPC

FIELD: organic chemistry. SUBSTANCE: product: derivatives of catechin of the general formula I, , where R₁ and R₂ are similar or different - H, lower acyl or phenylcarbonyl; X - halogen or nitro-group; R₃=[R₄R₅C=CH-], where at R₄ - H, then R₅ - phenylcarbonyl, non- or substituted with lower C₁-C₃-alkoxy, lower alkyl, hydroxyl, carboxyl- or nitro-group; at R₄ - lower alkyl, then R₅=C₁-C₃-acyl or hydroxy-C₁-C₃-alkyl or R₄=R₅-cyano- or lower alkoxycarbonyl, or R₄-cyano, and R₅ is C₁-C₅ alkoxycarbonyl, or R₅= -C(O)-NH₂ or -C(O)-NHR¹ or -C(O)-N(R¹)₂, where R¹ - lower alkyl or lower hydroxyalkyl, or R₅ - piperazinyl substituted with lower alkyl; R₃ - group [R₄R₅CH-CH], where R₄ - H, and R₅=-(CH)₂-C(O)-R], in which R - OH or NR″R″′, where R″=H - H and R″′ - adamantyl or C₁-C₄-alkyl or R″=C₁-C₄-alkyl and R″′-propinyl. Reaction conditions: condensation of compounds of the general formula II, , and III, , with active methyl or methylene group is carried in the presence of acid or base as a catalyst yielding unsaturated compound, where double bond can be reduced. EFFECT: improved method of synthesis.