METHOD OF SYNTHESIS OF 3,4-DIHYDROXY-5-NITROBENZALDEHYDE Russian patent published in 1999 - IPC

Abstract RU 2130449 C1

FIELD: organic chemistry and technology. SUBSTANCE: invention proposes a method of synthesis of 3,4-dihydroxy-5-nitrobenz- -aldehyde which is an important intermediate substance used in synthesis of some pharmaceutically essential compounds exhibiting 5-substituted 3-nitrocatechol structure, for example, entacapon. Method involves an interaction of 3-ethoxy-4-hydroxy-5-nitrobenzaldehyde with a reagent that contains zinc chloride, water and hydrogen chloride and the end product is obtained. Reagents used for synthesis can be recirculated easily. EFFECT: simplified method, decreased cost, high purity of end product. 10 cl, 1 ex

Similar patents RU2130449C1

Title	Year	Author	Number
METHOD OF SYNTHESIS OF 3,4-DIHYDROXY-5-NITROBENZALDEHYDE	1993	Ehrkki Khonkanen[Fi] Stig Lindkhol'M[Fi]	RU2098405C1
METHOD OF PREPARING DILTHIAZEM	1996	Martti Khjutenen	RU2139853C1
METHOD OF CATECHIN DERIVATIVES SYNTHESIS	1987	Reje Jokhannes Bjakstrem[Fi] Kalevi Ehvert Khejnola[Fi] Ehrkki Jukhani Khonkanen[Fi] Seppo Kalevi Kaakkola[Fi] Pekka Jukhani[Fi] Kajrisalo[Fi] Ivonne Inge-Britt Linden[Fi] Pekka Topias Mjanniste[Fi] Ehrkki Arne Olavi Nissinen[Fi] Pentti Pokhto[Fi] Aino Kjullikki Pippuri[Fi] Jarmo Iokhan Pjustjunen[Fi]	RU2014319C1
METHOD FOR OBTAINING SUBSTITUTED -DIKETONES	0	Pentti Pokhto Pyajvi Annikki Akho Rejjo Jokhannes Byakstrem Erkki Yukhani Khonkanen Inge-Britt Ivonne Linden Erkki Larne Olavi Nissinen	SU1836320A3
METHOD OF SYNTHESIS OF SUBSTITUTED IMIDAZOLE	1992	Arto Jokhannes Kar'Jalajnen[Fi] Lauri Vejkko Matti Kangas[Fi] Kauko Ojva Antero Kurkela[Fi]	RU2045519C1
DERIVATIVES OF CATECHOL AND METHOD FOR THEIR PRODUCTION	1991	Rejo Bjakstrem[Fi] Ehrkki Khonkanen[Fi] Inge-Britt Linden[Fi] Ehrkki Nissinen[Fi] Ajno Pippuri[Fi] Pentti Ponto[Fi] Tapio Korkolajnen[Fi]	RU2096407C1
METHOD FOR PHENOL COMPOUND NITRATION	2002	Lermont Dehvid Aleksander	RU2318797C2
METHOD OF SYNTHESIS OF SUBSTITUTED IMIDAZOLE OR ITS NONTOXIC PHARMACEUTICALLY ACCEPTABLE ACID-ADDITIVE SALT	1990	Kar'Jalajnen Arto Jokhannes[Fi] Pel'Konen Rejno Olavi[Fi] Sedervall Mar'Ja Liisa[Fi] Ljakhde Matti Antero[Fi] Lammintausta Risto Arvo Sakari[Fi] Kar'Jalajnen Ar'Ja Lena[Fi] Kalapudas Ar'Ja Marketta[Fi]	RU2021263C1
PERCUTANEOUS PREPARATION	1993	Majkl Uill'Jam Digrigorio Kauko Ojva Antero Kurkela	RU2140785C1
SUBSTITUTED 4(5)-IMIDAZOLES OR THEIR NONTOXIC PHARMACEUTICALLY ACCEPTABLE SALTS WITH ACIDS	1991	Arto Jokhannes Kar'Jalajnen[Fi] Ar'Ja Marketta Kalapudas[Fi] Rejno Olavi Pel'Konen[Fi] Mar'Ja-Liisa Sjadervall[Fi] Matti Antero Ljakhde[Fi] Risto Arvo Sakari Lammintausta[Fi]	RU2036193C1

RU 2 130 449 C1

Authors

Rejo Jokhannes Bekstrem

Dates

1999-05-20—Published

1995-09-20—Filed