FIELD: organic chemistry, pharmacology. SUBSTANCE: derivatives have formula (I) given in specification where R1 is electronegative substituent (e. g. nitro, halogen or cyano group); R2 is group which is chosen of compounds having formula (Ia) and (Ib) where R is hydrogen or alkyl, cycloalkyl, aralkyl or aryl where X1, X2, Y and Z are independently oxygen, sulfur or NR where R is as it mentioned above. Derivatives and pharmaceutically acceptable esters and salts thereof are useful as prophylaxis means for tissue injury induced by peroxidation of lipids and as treatment agent. EFFECT: improved quality. 11 cl, 1 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF CATECHIN DERIVATIVES SYNTHESIS | 1987 |
|
RU2014319C1 |
| METHOD OF SYNTHESIS OF 3,4-DIHYDROXY-5-NITROBENZALDEHYDE | 1993 |
|
RU2098405C1 |
| DERIVATIVES OF NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS WITH ALKALINE OR ALKALINE-EARTH METALS | 1992 |
|
RU2068844C1 |
| METHOD OF SYNTHESIS OF 3,4-DIHYDROXY-5-NITROBENZALDEHYDE | 1995 |
|
RU2130449C1 |
| METHOD OF SYNTHESIS OF HETEROCYCLIC COMPOUNDS AND HETEROCYCLIC COMPOUNDS | 1990 |
|
RU2048467C1 |
| METHOD OF SYNTHESIS OF SUBSTITUTED IMIDAZOLE | 1992 |
|
RU2045519C1 |
| METHOD OF SYNTHESIS OF SUBSTITUTED IMIDAZOLE OR ITS NONTOXIC PHARMACEUTICALLY ACCEPTABLE ACID-ADDITIVE SALT | 1990 |
|
RU2021263C1 |
| A METHOD FOR OBTAINING 5-[2-(4- AMINOPHENYL)ETHENYL] -5,6-DIHYDRO-1,3,4 -THIADIAZINE-2- (3H)-ONES | 0 |
|
SU1836362A3 |
| SUBSTITUTED 4(5)-IMIDAZOLES OR THEIR NONTOXIC PHARMACEUTICALLY ACCEPTABLE SALTS WITH ACIDS | 1991 |
|
RU2036193C1 |
| SUBSTITUTED EMIDAZOLES, METHODS OF PREPARATION THEREOF, PHARMACEUTICAL COMPOSITION BASED THEREON, AND METHOD OF MEDICAL TREATMENT | 1992 |
|
RU2120440C1 |
