FIELD: organic chemistry, pharmacology. SUBSTANCE: derivatives have formula (I) given in specification where R1 is electronegative substituent (e. g. nitro, halogen or cyano group); R2 is group which is chosen of compounds having formula (Ia) and (Ib) where R is hydrogen or alkyl, cycloalkyl, aralkyl or aryl where X1, X2, Y and Z are independently oxygen, sulfur or NR where R is as it mentioned above. Derivatives and pharmaceutically acceptable esters and salts thereof are useful as prophylaxis means for tissue injury induced by peroxidation of lipids and as treatment agent. EFFECT: improved quality. 11 cl, 1 tbl
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Authors
Dates
1997-11-20—Published
1991-04-26—Filed