METHOD OF SYNTHESIS OF SUBSTITUTED PYRROLS OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS Russian patent published in 1994 - IPC

FIELD: organic chemistry. SUBSTANCE: product: substituted pyrrols of the general formula I (image), where R - hydrogen or hydroxide; R¹ и R² are together - a group of formula -(CH₂)_n and R⁷ - hydrogen or R¹ и R⁷ are together - a group of formula -(CH₂)_n and R² - hydrogen; R³ - naphtyl, phenyl (unsubstituted or substituted with halogen), C₁-C₄-alkoxy or CF₃, benzo(b)-thienyl, benzofuranyl or 1-methyl-3-indolyl, unsubstituted or substituted at position 5 with halogen or C₁-C₄-alkoxy; R⁴, R⁵ и R⁶ hydrogen or C₁-C₄-alkoxy; R⁸- a group of formula (CH₂)_p-R⁹ or (CH₂)_q-R¹⁰; R⁹ - hydrogen, C₁-C₄-alkylcarbonyl, amino-C₁-C₄-alkylcarbonyl, cyano, amidino, phenoxycarbonyl, C₁-C₄-alkylsulfonyl, aminocarbonyl or aminothiocarbonyl; R¹⁰ - hydroxy, amino, mono-, di- or tri-C₁-C₄-alkylamino, acido, benzoylamino, C₁-C₄-alkanoylamino, C₁-C₄-alkoxycarbonylamino, isothiocyanato, C₁-C₄-alkylsulfonyloxy, C₁-C₄-alkyl-COO-, piperidino, amidinothio or 2-nitroguanidino; one of X and Y - 0-atom and other - 0 or (H,H)Z-group, CH or N-atom; m - a number from 0 to 3; n - a number 1 or 2, and p and q - from 0 to 2 at condition that m means 2 or 3 if Z - N-atom, or their pharmaceutically acceptable salts. Reagent 1: compound of the general formula II (image), where R¹-R⁷, R⁸, Z and m - as indicated above. Reagent 2: ammonia or hexamethyldisilazane and methanol, or hydroxylamine. Reaction conditions: in the medium of inert organic solvent at temperature 100-150, 40-110 and 100 C, respectively. Reagent 3: lithiumaluminium hydride. Reaction conditions: in the medium of inert organic solvent at temperature from 0 C to boiling point with reflux condenser. Synthesized compounds are used as inhibitors of protein kinase. EFFECT: improved method of synthesis.