PYRROLE TRICYCLIC DERIVATIVES, A PHARMACEUTICAL PREPARATION Russian patent published in 1999 - IPC

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to tricyclic derivatives of pyrrole of the general formula (I) where R¹-R⁴ mean hydrogen, halogen atom, lower alkyl, phenyl, cycloalkyl or lower alkoxy-group and R² means additionally lower alkoxycarbonyl, acyloxy or mesyloxy-group; R⁵ means lower alkyl; R⁶, R⁷ mean hydrogen atom or lower alkyl; X means CH₂CH(C₆H₅)-, -CH=C(C₆H₅)-, -YCH₂-,, -CH=CH- or C(R¹¹R¹²)_n;; R¹¹ and R¹² mean hydrogen atom, phenyl and lower alkyl, respectively; n = 1-3 and Y means O or S, and to pharmaceutically acceptable acid-additive salts also. Invention relates to also a pharmaceutical preparation showing capability to bind with serotonine receptors. Synthesized compounds are effective in prophylaxis and treatment of patients with central nervous system disorders, for example, depression, bipolar disorders, fear state, dream and sexual disorders, psychosis, migraines, schizophrenia and other morbid states associated with headache, disorders associated with personal senses or obsession, social phobia or panic attacks, psychic organic disorders, psychic disorders in children, memory disorders associated with age, disorders of contacts with other humans, morbid passion, obesity, bulimia and so on; disorders of nervous system functions caused by traumas, brain hemorrhage, nervous-degenerative sicknesses and so on; cardiovascular disorders, high blood pressure, thrombosis, insult and so on; gastroenteric disorders, dysfunction of gastroenteric tract motor activity. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 12 cl, 77 ex