IMIDAZOLE DERIVATIVES Russian patent published in 1994 - IPC

FIELD: organic chemistry. SUBSTANCE: products: derivatives of imidazoles of formula (I), where R₁ COOH or ; R₂ n-H-C₃H₇ or n-H-C₄H₉; R₃, Cl, CF₃, C₂F₅, C₆H₅ or COOH; R₄ COOH, CHO or CH₂OH at condition that a) when R₄-CH₂OH then R₃-C₂F₅ and R₂-H-C₃H₇; b) when R₃ COOH then R₄ is also COOH; c) when R₂-H-C₃H₇, R₃- C₂F₅ and R₄ COOH then R₁ is a group . Reagent 1: compound of formula (II), where R₂ as indicated above; R₅-Cl, CF₃,C₂F₅, C₆H₅ or COO(C₁-C₄)-alkyl; R₆-COO(C₁-C₄) -alkyl, CH₂OH or CHO. Reagent 2: compound of formula (III), where X halogen, p-toluenesulfonyloxy or methylsulfonyloxy; R₇-COO(C₁-C₄) -alkyl, CN or . Reaction conditions: in the medium of solvent in the presence of base at temperature from 20 C to solvent boiling point. Synthesized compounds are used in medicine. EFFECT: improved method of synthesis. 10 tbl