FIELD: veterinary science. SUBSTANCE: method involves preparing sterile sporulated oocysts, destroying them by ultrasound with preliminary homogenization, and comprises an additional step of fractionating the ultrasonic homogenizate by means of high-efficiency liquid high-pressure chromatography which ensures separation of protein fractions, mol. mass 100-200 kD, and is characterized by maximum antigenic activity and species specificity. Method has been tested by using various types of eimeria - E. tenella, E. maxima and E. acervulina. Eimerian antigens produced by claimed method ensure practically full absence of cross reactions in control immunochemical tests with the use of antiserums to various types of eimeria. EFFECT: increased activity and species specificity of eimerian antigens as compared with prototype. 2 tbl
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