DERIVATIVES OF 9-AMINOACRIDINE OR THEIR SALTS WITH ORGANIC OR INORGANIC ACIDS SHOWING PSYCHOTROPIC, ANTIAMNESTIC AND LIPID-REGULATING ACTIVITY Russian patent published in 1994 - IPC

FIELD: organic chemistry. SUBSTANCE: product - derivatives of 9-aminoacridine of the general formula (image) where R - H, CH₃; R₁ - H, CH₃, Br; R₂ - H, CH₃; R₃ - H, C₁-C₅-alkyl, arylmethyl, diethylaminoethyl; X - C=O, CHOH; Y - CH₂, X = Y - CH=CH, or their salts with organic or inorganic acids. Reagent 1: corresponding substituted anthranilic acid nitrile. Reagent 2: dimedone. Hydrochloride of substituted 2-[5,5-dimethyl-3-oxocyclohex-1-enyl)amino]benzonitrile prepared by reaction of reagent 1 and reagent 2 is cyclized following by alkylation of formed substituted 9-amino-3,3-dimethyl-3,4-dihydroacridine-1-2(H)-ones with alkyl- or arylalkylhalogenides to the corresponding alkyl (aralkyl)-derivatives, by ketones reduction to alcohols and alcohols dehydration to dihydro-derivatives by heating in alkanols in the presence in hydrochloric acid. Synthesized compounds are used as medicinal preparations. EFFECT: improved method of synthesis.