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2 027 709

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Application

4951704/04, 1991-06-28

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Actual filing date

1991-06-28

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Published

1995-01-27

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Inventor

Savel'Ev V.L.Mozhaeva T.Ja.Chichkanov G.G.Tsorin I.B.Kirsanova G.Ju.Kazanova G.V.Luk'Janova L.D.Chernobaeva G.N.Romanova V.E.Germanova Eh.L.Kaverina N.V.Berdjaev S.Ju.Olenina N.G.

(73)

Holder

Nauchno-Issledovatel'Skij Institut Farmakologii Ran

2-[2-(DIETHYLAMINO) -ETHYLTHIO]-5,6- DIMETHYLBENZIMIDAZOLE SALTS SHOWING ANTIISCHEMIC, ANTIHYPOXIC AND ANTIARRHYTHMIC ACTIVITY AND 2-[2-(DIETHYLAMINO) -ETHYLTHIO]-5,6- DIMETHYLBENZIMIDAZOLE AS AN INTERMEDIATE PRODUCT FOR SYNTHESIS OF 2-[2-(DIETHYLAMINO) -ETHYLTHIO] -5,6-DIMETHYLBENZIMIDAZOLE SALTS Russian patent published in 1995 - IPC

Abstract RU 2027709 C1

FIELD: organic chemistry. SUBSTANCE: product is used as a preparation showing antiischemic, antihypoxic and antiarrhythmic activity and 2-[2-(diethylamino) -ethylthio] -5,6- dimethylbenzimidazole as an intermediate product for synthesis of its dihydrochloride and succinate. Product of the general formula where I X - 2HCl; II X - 0,5(CH2COOH)2, product of the general formula . Reagent 1: 5,6-dimethyl -2-mercaptobenzimidazole. Reagent 2: 2-(diethylamino)-ethyl chloride in the medium of aqueous ethanol or dimethylformamide in the presence of the base. Reagent 3: ether solution of hydrogen chloride or spirituous solution of succinic acid. EFFECT: improved method of synthesis. 3 cl, 3 dwg, 9 tbl

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RU 2 027 709 C1

Authors

Savel'Ev V.L.

Mozhaeva T.Ja.

Chichkanov G.G.

Tsorin I.B.

Kirsanova G.Ju.

Kazanova G.V.

Luk'Janova L.D.

Chernobaeva G.N.

Romanova V.E.

Germanova Eh.L.

Kaverina N.V.

Berdjaev S.Ju.

Olenina N.G.

Dates

1995-01-27—Published

1991-06-28—Filed

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