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2 136 667

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Application

95106120/04, 1995-04-18

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Start date

1995-04-18

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Actual filing date

1995-04-18

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Published

1999-09-10

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Inventor

Seredenin S.B.Savel'Ev V.L.Mozhaeva T.Ja.Orlova Eh.K.Chichkanov G.G.Kaverina N.V.Tsorin I.B.Kirsanova G.Ju.

(73)

Holder

Nauchno-Issledovatel'Skij Institut Farmakologii Ramn

2-MERCAPTOBENZIMIDAZOLE DERIVATIVES SHOWING ANTI-ISCHEMIC, ANTI-ARRHYTHMIC AND ANTIFIBRILLATORY ACTIVITY Russian patent published in 1999 - IPC

Abstract RU 2136667 C1

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to new chemical compounds - derivatives of 2-mercaptobenzimidazole of the general formula (I) where n = 2, 3; R - hydrogen atom, benzyl, β-phenylethyl; R1 - dialkylamino-group, residue of monocyclic saturated amine that can contain an additional heteroatom - oxygen; R2 and R3 are similar or distinct and mean hydrogen atoms, lower alkyls, alkoxy-group at 5 or 6 position of benzene ring, benzimidazole, or their pharmaceutically acceptable salts showing anti-ischemic and anti-arrhythmic activities. The above indicated compounds show the expressed anti-ischemic, anti-arrhythmic and antifibrillatory effects and have the definite advantages over comparative preparations and can be used for treatment of patients with different diseases of cardiovascular system. EFFECT: valuable curative properties of compounds. 6 dwg, 12 tbl

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RU 2 136 667 C1

Authors

Seredenin S.B.

Savel'Ev V.L.

Mozhaeva T.Ja.

Orlova Eh.K.

Chichkanov G.G.

Kaverina N.V.

Tsorin I.B.

Kirsanova G.Ju.

Dates

1999-09-10—Published

1995-04-18—Filed

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