FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to new N-[2-(adamant-2-yl)aminocarbonylmethyl]-N'-(dialkylamino)alkylnitrobenzamide of general formula and their physiologically acceptable salts, preferentially hydrochlorides, which possess antiarhythmic action. In formula I, R can be hydrogen, alkyl (C1-C6) or cycloalkyl; R1 can be hydrogen or aliphatic residue (C1-C2); R2 can be alkyl (C1-C2) or saturated heterocycle together with nitrogen with one or two heteroatoms, such as morpholine, pyrrolidine, piperidine; "n" can have a value of 2 or 3; a nitro group in benzamide can be found in any position of the cycle.
EFFECT: invention refers to a method for preparing the compounds of general formula I, specific compounds of formula I, as well as to using them antiarhythmic, particularly antifibrillation agents.
8 cl, 11 tbl, 5 ex
Title | Year | Author | Number |
---|---|---|---|
SUBSTITUTED N-[2-(1-ADAMANTYLAMINO)-2-OXOETHYL]-N-(AMINOALKYL)AMIDES OF NITROBENZOIC ACIDS | 2011 |
|
RU2500666C2 |
DICYCLOHEXYLAMIDES OF N-SUBSTITUTED ALFA-AMINOCARBOXYLIC ACIDS HAVING ANTIARRHYTMIC AND ANTIFIBRILLARY ACTIVITY | 1994 |
|
RU2114821C1 |
SUCCINIC ACID ESTER 5-HYDROXYADAMANTAN-2-ONE, WHICH PREVENTS THE DEVELOPMENT OF CARDIAC ARRHYTHMIAS | 2020 |
|
RU2757477C1 |
2-MERCAPTOBENZIMIDAZOLE DERIVATIVES SHOWING ANTI-ISCHEMIC, ANTI-ARRHYTHMIC AND ANTIFIBRILLATORY ACTIVITY | 1995 |
|
RU2136667C1 |
1-(2,4,6-TRIMETHYLPHENYL)-2-[(2'-HYDROXY-3'-PHENYLOXY)-N-SUBSTITUTED-AMINOMETHYL]-PYRROLES AND THEIR SALTS ELICITING ANTI-ARRHYTHMIC AND ANTI-ISCHEMIC ACTIVITY | 2002 |
|
RU2231525C1 |
1-[ω-(N,N-SUBSTITUTED AMINO)-ALKYL]-2-(2-ACYLETHENYL)- -PYRROLES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS SHOWING ANTIARRHYTHMIC AND ANTIISCHEMIC ACTIVITY | 1993 |
|
RU2088573C1 |
PYRROLO[1,2-A]PYRAZINES OR THEIR FUMARATES SHOWING ANTIARRHYTHMIC AND ANTI-ISCHEMIC ACTIVITY | 2000 |
|
RU2194707C2 |
N-(2-(2-(DIALKYLAMINO)ETHOXY)ETHYL)CARBOXAMIDES AND HYDROCHLORIDES THEREOF, HAVING ANTIARRHYTHMIC ACTIVITY, AND PHARMACEUTICAL COMPOSITIONS BASED THEREON | 2019 |
|
RU2712638C1 |
N,N-BIS(2-(DIALKYLAMINO)ETHYL)CARBOXAMIDES AND THEIR DIHYDROCHLORIDES WITH ANTIARRHYTHMIC ACTIVITY AND PHARMACEUTICAL COMPOSITION BASED THEREON | 2017 |
|
RU2645080C1 |
2-[2-(DIETHYLAMINO) -ETHYLTHIO]-5,6- DIMETHYLBENZIMIDAZOLE SALTS SHOWING ANTIISCHEMIC, ANTIHYPOXIC AND ANTIARRHYTHMIC ACTIVITY AND 2-[2-(DIETHYLAMINO) -ETHYLTHIO]-5,6- DIMETHYLBENZIMIDAZOLE AS AN INTERMEDIATE PRODUCT FOR SYNTHESIS OF 2-[2-(DIETHYLAMINO) -ETHYLTHIO] -5,6-DIMETHYLBENZIMIDAZOLE SALTS | 1991 |
|
RU2027709C1 |
Authors
Dates
2015-04-10—Published
2013-04-05—Filed