N-[2-(ADAMANT-2-YL)AMINOCARBONYLMETHYL]-N'-(DIALKYLAMINO)ALKYLNITROBENZAMIDES POSSESSING ANTIARHYTHMIC ACTIVITY Russian patent published in 2015 - IPC C07C237/22 C07D295/13 C07C231/02 A61K31/166 A61P9/06 

Abstract RU 2547096 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to new N-[2-(adamant-2-yl)aminocarbonylmethyl]-N'-(dialkylamino)alkylnitrobenzamide of general formula and their physiologically acceptable salts, preferentially hydrochlorides, which possess antiarhythmic action. In formula I, R can be hydrogen, alkyl (C1-C6) or cycloalkyl; R1 can be hydrogen or aliphatic residue (C1-C2); R2 can be alkyl (C1-C2) or saturated heterocycle together with nitrogen with one or two heteroatoms, such as morpholine, pyrrolidine, piperidine; "n" can have a value of 2 or 3; a nitro group in benzamide can be found in any position of the cycle.

EFFECT: invention refers to a method for preparing the compounds of general formula I, specific compounds of formula I, as well as to using them antiarhythmic, particularly antifibrillation agents.

8 cl, 11 tbl, 5 ex

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RU 2 547 096 C2

Authors

Avdjunina Nina Ivanovna

Turilova Antonina Ivanovna

Pjatin Boris Mikhajlovich

Mirzojan Ruben Simonovich

Gan'Shina Tamara Sergeevna

Bol'Shakova Raisa Filippovna

Grushevskaja Ljubov' Nikolaevna

Alekseev Konstantin Viktorovich

Zherdev Vladimir Pavlovich

Dates

2015-04-10Published

2013-04-05Filed